Ampicillin (Principen) 500mg


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Ampicillin (Principen) 500mg

Ampicillin (Principen) 500mg is a broad-spectrum antibiotic that belongs to the penicillin class of medications. It is commonly used to treat bacterial infections such as pneumonia, strep throat, urinary tract infections, and ear infections. In this document, we will discuss the drug’s composition, mechanism of action, indications, dosage, and potential side effects.


Ampicillin is a white or yellowish powder that is typically packaged in capsules or tablets. Each tablet or capsule contains 500mg of ampicillin as its active ingredient. It also contains various inactive ingredients such as cornstarch, lactose, magnesium stearate, and microcrystalline cellulose.

Mechanism of Action

Ampicillin works by inhibiting the growth of bacteria by preventing the cross-linking of peptidoglycans, an essential component of the bacterial cell wall. This inhibition disrupts the structural integrity of the cell wall, causing the bacteria to lyse and die. Ampicillin is particularly effective against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae.


Ampicillin is indicated for the treatment of various bacterial infections, as outlined below:

1. Respiratory tract infections: Pneumonia, tonsillitis, bronchitis, and sinusitis.

2. Skin and soft-tissue infections: Cellulitis, abscesses, and wounds.

3. Gastrointestinal infections: Gastroenteritis, typhoid fever, and shigellosis.

4. Genitourinary tract infections: Urinary tract infections, prostatitis, and gonorrhea.

5. Bone and joint infections: Osteomyelitis and septic arthritis.


The dosage and duration of ampicillin therapy vary depending on the specific condition being treated and the patient’s individual response. Generally, adults are given 500mg to 1g of ampicillin orally every 6 to 12 hours, depending on the infection severity and organism sensitivity. The dosage for children is usually calculated based on their weight and age.

It is important to follow the doctor’s instructions regarding the correct dosage and duration of treatment. Ampicillin should be taken on an empty stomach, usually one hour before or two hours after eating.

Side Effects

While ampicillin is generally consideres safe, it may cause certain side effects in some individuals. The most common adverse reactions include:

1- Nausea and vomiting

2- Diarrhea or loose stools

3- Abdominal pain

4- Stools that are bloody or contain mucus

5- Headache

6- Skin rashes

7- Itching

8- Swelling of the tongue or throat

9- Seizures

If you experience any of these side effects, it is advisable to contact your healthcare provider for further evaluation and guidance.


Ampicillin is a commonly use antibiotic that effectively treats bacterial infections. Its broad-spectrum activity against both Gram-positive and Gram-negative bacteria makes it a valuable therapeutic option for the treatment of various infections. However, it is essential to follow the prescribed dosage and consult with your healthcare provider if you experience any adverse reactions.

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