Fentora (Fentanyl Buccal Tablet)


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Fentora (Fentanyl Buccal Tablet)

Fentora (Fentanyl Buccal Tablet) is a prescription medication used to treat severe chronic pain in adults who have failed to get adequate pain relief from alternative treatments. It is specifically indicated for the management of breakthrough pain in patients with cancer.

Mechanism of Action

Fentora belongs to the class of drugs known as opioid analgesics. It works by binding to the brain’s opioid receptors, reducing the perception of pain and enhancing the feeling of well-being. The medication is designed to provide relief from severe breakthrough pain episodes, which can occur despite ongoing treatment with regular pain medications.

Dosage and Administration

The recommended dosage of Fentora is 400 micrograms (mcg) administered as a buccal tablet placed in the cheek pouch. The tablet should be dissolved slowly in the mouth over a period of about 30 seconds. It should not be chewed or swallowed whole. The maximum daily dose is 800 mcg, and it should be taken as-needed, not more than once every 12 hours.

Side Effects

Fentora may cause some common side effects such as nausea, vomiting, constipation, dizziness, drowsiness, and dry mouth. These side effects are usually temporary and should resolve on their own. However, if they persist or become severe, it is important to inform your healthcare provider.


Fentora should not be used in people with severe respiratory depression or acute or severe liver disease. It is also contraindicated in patients with a history of substance abuse or addiction, as the use of opioids may increase the risk for addiction and misuse.

Warnings and Precautions

Fentora should be used with caution in people with decreased respiratory function, obstructive sleep apnea, or increased sensitivity to opioids. It should also be used with caution in older adults, who are more prone to the side effects associated with opioids.

Drug Interactions

Fentora may interact with certain medications, including monoamine oxidase inhibitors (MAOIs), rifampin, and St. John’s wort. It is important to tell your healthcare provider about all the medications you are taking, including any over-the-counter medications, vitamins, or herbal supplements.

Overdose and Withdrawal

An overdose of Fentora can lead to respiratory depression and death. If you suspect an overdose, seek medical attention immediately. Withdrawal symptoms can occur if Fentora is suddenly stopped or significantly decreased, including nausea, vomiting, sweating, irritability, and restlessness.


Fentora (Fentanyl Buccal Tablet) is a prescription medication used for the treatment of severe chronic pain in adults who have failed to get adequate pain relief from alternative treatments. It provides relief from breakthrough pain episodes in patients with cancer. While effective, this medication should be used with caution and under the supervision of a healthcare professional.

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